Joel D Leverson: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

Don't use scam websites

1

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz,

Journal:

Nature Medicine

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

2

Clearance of therapyâinduced senescent tumor cells by the senolytic ABTâ263 via interference with BCLâX L âBAX Interaction

Saleh, Tareq, Carpenter, Valerie J., TyutyunykâMassey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony, Reed, Jason, Harada, Hisashi, Gewirtz, David

Journal:

Molecular Oncology

Year:

2020

File:

PDF, 80.37 MB

2020

3

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Ashkenazi, Avi, Fairbrother, Wayne J., Leverson, Joel D., Souers, Andrew J.

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 752 KB

english, 2017

4

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Yunsong Tong, Kent D. Stewart, Sheela Thomas, Magdalena Przytulinska, Eric F. Johnson, Vered Klinghofer, Joel Leverson, Owen McCall, Niru B. Soni, Yan Luo, Nan-horng Lin, Thomas J. Sowin, Vincent L. G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 490 KB

english, 2008

5

Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines

Lam, Lloyd T, Zhang, Haichao, Xue, John, Leverson, Joel D, Bhathena, Anahita

Journal:

Cancer Cell International

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

6

Clearance of systemic hematologic tumors by venetoclax (Abt-199) and navitoclax

Ackler, Scott, Oleksijew, Anatol, Chen, Jun, Chyla, Brenda J., Clarin, Jerry, Foster, Kelly, McGonigal, Thomas, Mishra, Sasmita, Schlessinger, Sally, Smith, Morey L., Tahir, Stephen K., Leverson, Joel

Journal:

Pharmacology Research & Perspectives

Year:

2015

Language:

english

File:

PDF, 5.67 MB

english, 2015

7

Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo

Zhou, Liang, Zhang, Yu, Sampath, Deepak, Leverson, Joel, Dai, Yun, Kmieciak, Maciej, Nguyen, Matthew, Orlowski, Robert Z, Grant, Steven

Journal:

British Journal of Cancer

Year:

2017

Language:

english

File:

PDF, 1.33 MB

english, 2017

8

Combined MEK and BCL-2/XL inhibition is effective in high-grade serous ovarian cancer patient-derived xenograft models and BIM levels are predictive of responsiveness

Iavarone, Claudia, Zervantonakis, Ioannis K., Selfors, Laura M, Palakurthi, Sangeetha, Liu, Joyce F., Drapkin, Ronny, Matulonis, Ursula A, Hallberg, Dorothy, Velculescu, Victor E., Leverson, Joel D.,

Journal:

Molecular Cancer Therapeutics

Year:

2019

File:

PDF, 2.21 MB

2019

9

Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins

Sun, Huaiyu, Leverson, Joel D, Hunter, Tony

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 412 KB

english, 2007

10

Aminopyrimidinone Cdc7 Kinase Inhibitors

Keith W. Woods, Chunqiu Lai, Julie M. Miyashiro, Yunsong Tong, Alan S. Florjancic, Edward K. Han, Niru Soni, Yan Shi, Loren Lasko, Joel D. Leverson, Eric F. Johnson, Alexander R. Shoemaker, Thomas D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.44 MB

english, 2012

11

Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment?

Leverson, Joel D., Cojocari, Dan

Journal:

Frontiers in Oncology

Year:

2018

Language:

english

File:

PDF, 755 KB

english, 2018

12

A New Staple: Peptide-Targeted Covalent Inhibitors

Leverson, Joel D.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 195 KB

english, 2016

13

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

Tong, Yunsong, Bouska, Jennifer J., Ellis, Paul A., Johnson, Eric F., Leverson, Joel, Liu, Xuesong, Marcotte, Patrick A., Olson, Amanda M., Osterling, Donald J., Przytulinska, Magdalena, Rodriguez, Lu

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.07 MB

english, 2009

14

Pim-1 Kinase and p100 Cooperate to Enhance c-Myb Activity

Joel D Leverson, Päivi J Koskinen, Frank C Orrico, Eeva-Marja Rainio, Katriina J Jalkanen, Ajeeta B Dash, Robert N Eisenman, Scott A Ness

Journal:

Year:

1998

Language:

english

File:

PDF, 157 KB

english, 1998

15

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis

Jin, Sha, Cojocari, Dan, Purkal, Julie J., Popovic, Relja, Talaty, Nari N., Xiao, Yu, Solomon, Larry R., Boghaert, Erwin R., Leverson, Joel D., Phillips, Darren C.

Journal:

Clinical Cancer Research

Year:

2020

File:

PDF, 8.54 MB

2020

16

New opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response

Luo, Yan, Leverson, Joel D

Journal:

Expert Review of Anticancer Therapy

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

17

Combined Targeting of Bcl-2 and Bcr-Abl Tyrosine Kinase Eradicates Chronic Myeloid Leukemia Stem/Progenitor Cells

Carter, Bing Z., Mak, Po Yee, Mu, Hong, Zhou, Hongsheng, Mak, Duncan H., Schober, Wendy, Leverson, Joel D., Zhang, Bin, Bhatia, Ravi, Cortes, Jorge, Kantarjian, Hagop, Konopleva, Marina, Andreeff, Mic

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2015

Language:

english

File:

PDF, 59 KB

english, 2015

18

Genetic Biomarkers Of Sensitivity and Resistance to Venetoclax Monotherapy in Patients With Relapsed Acute Myeloid Leukemia

Chyla, Brenda, Daver, Naval, Doyle, Kelly, McKeegan, Evelyn, Huang, Xin, Ruvolo, Vivian, Wang, Zixing, Chen, Ken, Souers, Andrew, Leverson, Joel, Potluri, Jalaja, Boghaert, Erwin, Bhathena, Anahita, K

Journal:

American Journal of Hematology

Year:

2018

Language:

english

File:

PDF, 892 KB

english, 2018

19

Chemical Parsing: Dissecting Cell Dependencies with a Toolkit of Selective BCL-2 Family Inhibitors

Leverson, Joel D.

Journal:

Molecular & Cellular Oncology

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

20

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

Zoeller, Jason J., Vagodny, Aleksandr, Daniels, Veerle W., Taneja, Krishan, Tan, Benjamin Y., DeRose, Yoko S., Fujita, Maihi, Welm, Alana L., Letai, Anthony, Leverson, Joel D., Blot, Vincent, Bronson,

Journal:

Breast Cancer Research

Year:

2020

File:

PDF, 4.73 MB

2020

21

Point Mutations in v-Myb Disrupt a Cyclophilin-Catalyzed Negative Regulatory Mechanism

Joel D Leverson, Scott A Ness

Journal:

Year:

1998

Language:

english

File:

PDF, 225 KB

english, 1998

22

Discovery of 3 H -Benzo[4,5]thieno[3,2- d ]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Tao, Zhi-Fu, Hasvold, Lisa A., Leverson, Joel D., Han, Edward K., Guan, Ran, Johnson, Eric F., Stoll, Vincent S., Stewart, Kent D., Stamper, Geoff, Soni, Nirupama, Bouska, Jennifer J., Luo, Yan, Sowin

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.89 MB

english, 2009

23

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

Pan, Rongqing, Ruvolo, Vivian, Mu, Hong, Leverson, Joel D., Nichols, Gwen, Reed, John C., Konopleva, Marina, Andreeff, Michael

Journal:

Year:

2017

Language:

english

File:

PDF, 6.18 MB

english, 2017

24

Functional profiling of venetoclax sensitivity can predict clinical response in multiple myeloma

Matulis, Shannon M., Gupta, Vikas A., Neri, Paola, Bahlis, Nizar J., Maciag, Paulo, Leverson, Joel D., Heffner, Leonard T., Lonial, Sagar, Nooka, Ajay K., Kaufman, Jonathan L., Boise, Lawrence H.

Journal:

Year:

2019

File:

PDF, 409 KB

2019

25

Combined MEK and BCL-2/XL inhibition is effective in high-grade serous ovarian cancer patient-derived xenograft models and BIM levels are predictive of responsiveness

Iavarone, Claudia, Zervantonakis, Ioannis K., Selfors, Laura M, Palakurthi, Sangeetha, Liu, Joyce F., Drapkin, Ronny, Matulonis, Ursula A, Hallberg, Dorothy, Velculescu, Victor E., Leverson, Joel D.,

Journal:

Molecular Cancer Therapeutics

Year:

2019

Language:

english

File:

PDF, 2.21 MB

english, 2019

26

Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer

Zhang, Haichao, Xue, John, Hessler, Paul, Tahir, Stephen K., Chen, Jun, Jin, Sha, Souers, Andrew J., Leverson, Joel D., Lam, Lloyd T.

Journal:

Molecular Cancer

Year:

2015

Language:

english

File:

PDF, 1.78 MB

english, 2015

27

Co-targeting BCL-2 and PI3K induces BAX-dependent mitochondrial apoptosis in AML cells

Rahmani, Mohamed, Nkwocha, Jewel, Hawkins, Elisa, Pei, Xinyan, Parker, Rebecca E, Kmieciak, Maciej, Leverson, Joel D., Sampath, Deepak, Ferreira-Gonzalez, Andrea, Grant, Steven

Journal:

Cancer Research

Year:

2018

Language:

english

File:

PDF, 1.46 MB

english, 2018

28

Synergistic induction of apoptotic cell death in AML by targeting Bcl-2 with ABT-199 in combination with Bcl-Xl/ Mcl-1 inhibition or selective kinase inhibitors

Zhang, Qi, Han, Lina, Pan, Rongqing, Shi, Ce, Ma, Helen, Leverson (Abbvie), Joel, Konopleva, Marina

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2015

Language:

english

File:

PDF, 59 KB

english, 2015

29

Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models

Han, Lina, Zhang, Qi, Shi, Ce, Cavazos, Antonio, Ruvolo, Vivian R., Leverson, Joel D., Dail, Monique, Phillips, Darren C., Chen, Jun, Jin, Sha S., Jacamo, Rodrigo, Daver, Naval, Jabbour, Elias, Kantar

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2017

Language:

english

File:

PDF, 59 KB

english, 2017

30

Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax

Leverson, Joel D., Sampath, Deepak, Souers, Andrew J., Rosenberg, Saul H., Fairbrother, Wayne J., Amiot, Martine, Konopleva, Marina, Letai, Anthony

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 5.76 MB

english, 2017

31

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response

Zervantonakis, Ioannis K., Iavarone, Claudia, Chen, Hsing-Yu, Selfors, Laura M., Palakurthi, Sangeetha, Liu, Joyce F., Drapkin, Ronny, Matulonis, Ursula, Leverson, Joel D., Sampath, Deepak, Mills, Gor

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 1.94 MB

english, 2017

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@z-lib.do

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски